mini_gene (RELEASE_2.1) |
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|---|---|
| SO Accession: | SO:0000815 (SOWiki) |
| Definition: | By definition, minigenes are short open-reading framesn(ORF), usually encoding approximately 9 to 20 aminonacids, which are expressed in vivo (as distinct from beingnsynthesized as peptide or protein ex vivo and subsequentlyninjected). The in vivo synthesis confers a distinctnadvantage: the expressed sequences can enter bothnantigen presentation pathways, MHC I (inducing CD8+ T-ncells, which are usually cytotoxic T-lymphocytes (CTL))nand MHC II (inducing CD4+ T-cells, usually 'T-helpers'n(Th)); and can encounter B-cells, inducing antibodynresponses. Three main vector approaches have been usednto deliver minigenes: viral vectors, bacterial vectors andnplasmid DNA. |
| DB Xrefs: | URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15992153&query_hl=2&itool=pubmed_docsum |
| Parent: | ORF (SO:0000236) |
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