CRM (RELEASE_2.5.3) |
|
|---|---|
| SO Accession: | SO:0000727 (SOWiki) |
| Definition: | A regulatory region where transcription factor binding sites clustered to regulate various aspects of transcription activities. (CRMs can be located a few kb to hundred kb upstream of the basal promoter, in the coding sequence, within introns, or in the downstream 3'UTR sequences, as well as on different chromosome). A single gene can be regulated by multiple CRMs to give precise control of its spatial and temporal expression. CRMs function as nodes in large, intertwined regulatory network. |
| Synonyms: | cis regulatory module, TF module, transcription factor module |
| DB Xrefs: | PMID: 19660565 |
| SO: SG | |
| Parents: | transcriptional_cis_regulatory_region (SO:0001055) |
| TF_binding_site (SO:0000235) | |
| Children: | silencer (SO:0000625) |
| locus_control_region (SO:0000037) | |
| enhancer (SO:0000165) | |
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