miRNA
SO:0000276
Definition: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes). Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
Comments and references
Definition references: PMID:11081512, PMID:12592000
Synonyms
| Scope | Value |
|---|---|
| exact | INSDC_qualifier:miRNA |
| exact | micro RNA |
| exact | microRNA |
| exact | small temporal RNA |
| exact | stRNA |
| broad | INSDC_feature:ncRNA |
Identifiers and subsets
Accession: SO:0000276
Persistent URL: http://purl.obolibrary.org/obo/SO_0000276
Alternate IDs: SO:0000649
Subsets: SOFA
Cross references: http://en.wikipedia.org/wiki/MiRNA, http://en.wikipedia.org/wiki/StRNA
History summary
Term history is reconstructed from the Git-era ontology files by comparing ontology classes across revisions. Earlier SVN-era changes will be added at a future date.
First seen in Git-era editable history: 2016-12-05 in commit 92e3cae
Most recent Git-era change: 2024-06-05 in commit 0bdfaad
Number of changes: 5
Ontology neighborhood diagram
Relationships
http://purl.obolibrary.org/obo/so#derives_from (outgoing)
Change history
This timeline summarizes changes identified in SO’s GitHub commit history, including updates to labels, definitions, parent terms, synonyms, subsets, and obsoletion status. It is a best-effort reconstruction and may not include every change to a term. Since only history from GitHub is included at the moment, any term added before the migration from SVN to Git will show as being created in 2016. This will be addressed once SVN history is incorporated.
| Date | Change | Summary | Evidence |
|---|---|---|---|
| 2024-06-05 | definition changed | Definition updated Before: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors. After: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes). Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors. | 0bdfaad |
| 2021-11-11 | definition changed | Definition updated Before: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors. After: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0001244) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors. | 34301f2 |
| 2018-01-26 | synonym added | Synonym added: INSDC_qualifier:miRNA Scope: exact | 5fe48bd |
| 2018-01-26 | synonym added | Synonym added: INSDC_feature:ncRNA Scope: broad | 5fe48bd |
| 2016-12-05 | created | Term introduced into the editable ontology history Initial label: miRNA Initial definition captured. Initial parent: SO:0000370 | 92e3cae |